******************************************************************************** MAST - Motif Alignment and Search Tool ******************************************************************************** MAST version 4.3.2 (Release date: Wed Dec 23 18:09:18 EST 2009) For further information on how to interpret these results or to get a copy of the MAST software please access http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Michael Gribskov, "Combining evidence using p-values: application to sequence homology searches", Bioinformatics, 14(48-54), 1998. ******************************************************************************** ******************************************************************************** DATABASE AND MOTIFS ******************************************************************************** DATABASE tests/adh.s (peptide) Last updated on Mon Feb 15 12:10:18 2010 Database contains 33 sequences, 9996 residues MOTIFS tests/meme/meme.adh.zoops (peptide) MOTIF WIDTH BEST POSSIBLE MATCH ----- ----- ------------------- 1 21 GKVVLITGCSSGIGKATAKHL 2 29 SVYCASKFAVRMLTRSMAMEYAPHGIRVN PAIRWISE MOTIF CORRELATIONS: MOTIF 1 ----- ----- 2 0.30 No overly similar pairs (correlation > 0.60) found. Random model letter frequencies (from non-redundant database): A 0.073 C 0.018 D 0.052 E 0.062 F 0.040 G 0.069 H 0.022 I 0.056 K 0.058 L 0.092 M 0.023 N 0.046 P 0.051 Q 0.041 R 0.052 S 0.074 T 0.059 V 0.064 W 0.013 Y 0.033 ******************************************************************************** ******************************************************************************** SECTION I: HIGH-SCORING SEQUENCES ******************************************************************************** - Each of the following 33 sequences has E-value less than 10. - The E-value of a sequence is the expected number of sequences in a random database of the same size that would match the motifs as well as the sequence does and is equal to the combined p-value of the sequence times the number of sequences in the database. - The combined p-value of a sequence measures the strength of the match of the sequence to all the motifs and is calculated by o finding the score of the single best match of each motif to the sequence (best matches may overlap), o calculating the sequence p-value of each score, o forming the product of the p-values, o taking the p-value of the product. - The sequence p-value of a score is defined as the probability of a random sequence of the same length containing some match with as good or better a score. - The score for the match of a position in a sequence to a motif is computed by by summing the appropriate entry from each column of the position-dependent scoring matrix that represents the motif. - Sequences shorter than one or more of the motifs are skipped. - The table is sorted by increasing E-value. ******************************************************************************** SEQUENCE NAME DESCRIPTION E-VALUE LENGTH ------------- ----------- -------- ------ BUDC_KLETE ACETOIN(DIACETYL) REDUCTA... 1.3e-32 241 YRTP_BACSU HYPOTHETICAL 25.3 KD PROT... 1.4e-32 238 FIXR_BRAJA FIXR PROTEIN 3.5e-28 278 AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP... 1.1e-26 244 HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DE... 1.6e-26 255 DHGB_BACME GLUCOSE 1-DEHYDROGENASE B... 4.8e-26 262 HDE_CANTR HYDRATASE-DEHYDROGENASE-E... 2.3e-25 906 DHII_HUMAN CORTICOSTEROID 11-BETA-DE... 2.3e-25 292 NODG_RHIME NODULATION PROTEIN G (HOS... 2.7e-25 245 YINL_LISMO HYPOTHETICAL 26.8 KD PROT... 2.9e-25 248 DHB2_HUMAN no comment 3.1e-25 387 RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (... 8.7e-25 249 DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYD... 1.3e-24 270 FVT1_HUMAN no comment 2.1e-24 332 ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXY... 6.7e-24 248 2BHD_STREX 20-BETA-HYDROXYSTEROID DE... 1.5e-23 255 BDH_HUMAN D-BETA-HYDROXYBUTYRATE DE... 2.4e-23 343 HMTR_LEIMA no comment 4.4e-23 287 DHES_HUMAN ESTRADIOL 17 BETA-DEHYDRO... 2e-22 327 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEH... 5.3e-22 253 BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DE... 5.5e-22 249 GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DE... 3e-21 259 DHB3_HUMAN no comment 3.9e-21 310 BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDRO... 5.4e-19 275 LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC... 6.7e-19 305 RFBB_NEIGO no comment 6.9e-19 346 DHCA_HUMAN no comment 1.5e-17 276 ADH_DROME ALCOHOL DEHYDROGENASE (EC... 1.5e-14 255 FABI_ECOLI no comment 5.3e-14 262 YURA_MYXXA no comment 7.1e-13 258 PCR_PEA no comment 8.2e-11 399 MAS1_AGRRA no comment 2.7e-09 476 CSGA_MYXXA no comment 4.5e-08 166 ******************************************************************************** ******************************************************************************** SECTION II: MOTIF DIAGRAMS ******************************************************************************** - The ordering and spacing of all non-overlapping motif occurrences are shown for each high-scoring sequence listed in Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001. - The POSITION p-value of a match is the probability of a single random subsequence of the length of the motif scoring at least as well as the observed match. - For each sequence, all motif occurrences are shown unless there are overlaps. In that case, a motif occurrence is shown only if its p-value is less than the product of the p-values of the other (lower-numbered) motif occurrences that it overlaps. - The table also shows the E-value of each sequence. - Spacers and motif occurences are indicated by o -d- `d' residues separate the end of the preceding motif occurrence and the start of the following motif occurrence o [n] occurrence of motif `n' with p-value less than 0.0001. ******************************************************************************** SEQUENCE NAME E-VALUE MOTIF DIAGRAM ------------- -------- ------------- BUDC_KLETE 1.3e-32 1_[1]_127_[2]_63 YRTP_BACSU 1.4e-32 5_[1]_126_[2]_57 FIXR_BRAJA 3.5e-28 35_[1]_130_[2]_63 AP27_MOUSE 1.1e-26 6_[1]_119_[2]_69 HDHA_ECOLI 1.6e-26 10_[1]_125_[2]_70 DHGB_BACME 4.8e-26 6_[1]_130_[2]_76 HDE_CANTR 2.3e-25 7_[1]_132_[2]_132_[1]_122_[2]_413 DHII_HUMAN 2.3e-25 33_[1]_126_[2]_83 NODG_RHIME 2.7e-25 5_[1]_123_[2]_67 YINL_LISMO 2.9e-25 4_[1]_126_[2]_68 DHB2_HUMAN 3.1e-25 81_[1]_127_[2]_129 RIDH_KLEAE 8.7e-25 13_[1]_123_[2]_63 DHMA_FLAS1 1.3e-24 13_[1]_128_[2]_79 FVT1_HUMAN 2.1e-24 31_[1]_131_[2]_120 ENTA_ECOLI 6.7e-24 4_[1]_116_[2]_78 2BHD_STREX 1.5e-23 5_[1]_3_[1]_99_[2]_77 BDH_HUMAN 2.4e-23 54_[1]_130_[2]_109 HMTR_LEIMA 4.4e-23 5_[1]_164_[2]_68 DHES_HUMAN 2e-22 1_[1]_130_[2]_146 3BHD_COMTE 5.3e-22 5_[1]_122_[2]_76 BA72_EUBSP 5.5e-22 5_[1]_128_[2]_66 GUTD_ECOLI 3e-21 1_[1]_129_[2]_79 DHB3_HUMAN 3.9e-21 47_[1]_127_[2]_86 BPHB_PSEPS 5.4e-19 4_[1]_125_[2]_96 LIGD_PSEPA 6.7e-19 5_[1]_128_[2]_122 RFBB_NEIGO 6.9e-19 5_[1]_136_[2]_155 DHCA_HUMAN 1.5e-17 3_[1]_166_[2]_57 ADH_DROME 1.5e-14 5_[1]_123_[2]_77 FABI_ECOLI 5.3e-14 5_[1]_130_[2]_77 YURA_MYXXA 7.1e-13 157_[2]_72 PCR_PEA 8.2e-11 85_[1]_293 MAS1_AGRRA 2.7e-09 244_[1]_124_[2]_58 CSGA_MYXXA 4.5e-08 85_[2]_52 ******************************************************************************** ******************************************************************************** SECTION III: ANNOTATED SEQUENCES ******************************************************************************** - The positions and p-values of the non-overlapping motif occurrences are shown above the actual sequence for each of the high-scoring sequences from Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001 as defined in Section II. - For each sequence, the first line specifies the name of the sequence. - The second (and possibly more) lines give a description of the sequence. - Following the description line(s) is a line giving the length, combined p-value, and E-value of the sequence as defined in Section I. - The next line reproduces the motif diagram from Section II. - The entire sequence is printed on the following lines. - Motif occurrences are indicated directly above their positions in the sequence on lines showing o the motif number of the occurrence, o the position p-value of the occurrence, o the best possible match to the motif, and o columns whose match to the motif has a positive score (indicated by a plus sign). ******************************************************************************** BUDC_KLETE ACETOIN(DIACETYL) REDUCTASE (EC 1.1.1.5) (ACETOIN DEHYDROGENASE) LENGTH = 241 COMBINED P-VALUE = 3.95e-34 E-VALUE = 1.3e-32 DIAGRAM: 1_[1]_127_[2]_63 [1] 8.9e-19 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++++ 1 MQKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATATAVAAEINQAGGRAVAIKVDVSRRDQVFAAVEQARK [ 1 S + 76 ALGGFNVIVNNAGIAPSTPIESITEEIVDRVYNINVKGVIWGMQAAVEAFKKEGHGGKIVNACSQAGHVGNPELA 2] .1e-22 VYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++++++++ +++++ 151 VYSSSKFAVRGLTQTAARDLAPLGITVNGFCPGIVKTPMWAEIDRQCRKRRANRWATARLNLPNASPLAACRSLK YRTP_BACSU HYPOTHETICAL 25.3 KD PROTEIN IN RTP 5'REGION (ORF238) LENGTH = 238 COMBINED P-VALUE = 4.17e-34 E-VALUE = 1.4e-32 DIAGRAM: 5_[1]_126_[2]_57 [1] 2.8e-17 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++++ 1 MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVKAAFAAADVKDADQVNQAVA [2] 4.0e-24 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++ ++++++++++++++++++ 151 VTSAYSASKFAVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVAQLKLDPR FIXR_BRAJA FIXR PROTEIN LENGTH = 278 COMBINED P-VALUE = 1.05e-29 E-VALUE = 3.5e-28 DIAGRAM: 35_[1]_130_[2]_63 [1] 8.4e-16 GKVVLITGCSSGIGKATAKHL ++++ +++++++++++++ + 1 MGLDLPNDNLIRGPLPEAHLDRLVDAVNARVDRGEPKVMLLTGASRGIGHATAKLFSEAGWRIISCARQPFDGER [2] 2.7e-21 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ +++++ ++++++++++++++++++ 151 APILLAQGLFDELRAASGSIVNVTSIAGSRVHPFAGSAYATSKAALASLTRELAHDYAPHGIRVNAIAPGEIRTD AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP27) LENGTH = 244 COMBINED P-VALUE = 3.19e-28 E-VALUE = 1.1e-26 DIAGRAM: 6_[1]_119_[2]_69 [1] 9.5e-15 GKVVLITGCSSGIGKATAKHL + +++++++++++++ +++++ 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIG [2] 1.0e SVYC ++ 76 PVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYS -20 ASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++++++ ++++ 151 STKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSD HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (HSDH) LENGTH = 255 COMBINED P-VALUE = 4.97e-28 E-VALUE = 1.6e-26 DIAGRAM: 10_[1]_125_[2]_70 [1] 1.9e-16 GKVVLITGCSSGIGKATAKHL ++++++++++ ++++++++++ 1 MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQEL [2] 7.3e-19 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ +++++ +++++ +++++++++++++ 151 NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIA DHGB_BACME GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1.47) LENGTH = 262 COMBINED P-VALUE = 1.44e-27 E-VALUE = 4.8e-26 DIAGRAM: 6_[1]_130_[2]_76 [1] 3.4e-15 GKVVLITGCSSGIGKATAKHL ++++++++++ ++++++++++ 1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVIN [2] 1.1e-19 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++ +++++++ +++++++++++++++++ 151 KIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEE HDE_CANTR HYDRATASE-DEHYDROGENASE-EPIMERASE (HDE) LENGTH = 906 COMBINED P-VALUE = 7.01e-27 E-VALUE = 2.3e-25 DIAGRAM: 7_[1]_132_[2]_132_[1]_122_[2]_413 [1] 1.9e-13 GKVVLITGCSSGIGKATAKHL +++++++++++++++ +++++ 1 MSPVDFKDKVVIITGAGGGLGKYYSLEFAKLGAKVVVNDLGGALNGQGGNSKAADVVVDEIVKNGGVAVADYNNV [2] 9.7e-14 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ +++ ++ ++ ++++++ ++++++ + 151 PAGLYGNFGQANYASAKSALLGFAETLAKEGAKYNIKANAIAPLARSRMTESILPPPMLEKLGPEKVAPLVLYLS [1] 3.2e-17 GKVVLITGCSSGIGKATAKHL ++++++++++ ++++++++++ 301 TNEARKLPANDASGAPTVSLKDKVVLITGAGAGLGKEYAKWFAKYGAKVVVNDFKDATKTVDEIKAAGGEAWPDQ [2] 4.3e-18 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++ +++++++ + ++ +++++ 451 NITSTSGIYGNFGQANYSSSKAGILGLSKTMAIEGAKNNIKVNIVAPHAETAMTLTIFREQDKNLYHADQVAPLL DHII_HUMAN CORTICOSTEROID 11-BETA-DEHYDROGENASE (EC 1.1.1.146) (11-DH) (11-BETA- HYDROXYSTEROID DEHYDROGENASE) (11-BETA-HSD) LENGTH = 292 COMBINED P-VALUE = 7.06e-27 E-VALUE = 2.3e-25 DIAGRAM: 33_[1]_126_[2]_83 [1] 1.1e-17 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++++ 1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV [2] 1.4e-16 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++++++ ++ +++++ ++++++ 151 TVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK NODG_RHIME NODULATION PROTEIN G (HOST-SPECIFICITY OF NODULATION PROTEIN C) LENGTH = 245 COMBINED P-VALUE = 8.16e-27 E-VALUE = 2.7e-25 DIAGRAM: 5_[1]_123_[2]_67 [1] 7.3e-13 GKVVLITGCSSGIGKATAKHL + +++++++++ ++ ++++ + 1 MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQIEKLETLATELGDRVKLFPANLANRDEVKALGQRAE [ 3 S + 76 ADLEGVDILVNNAGITKDGLFLHMADPDWDIVLEVNLTAMFRLTREITQQMIRRRNGRIINVTSVAGAIGNPGQT 2] .5e-21 VYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++++++++ +++++ 151 NYCASKAGMIGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLAS YINL_LISMO HYPOTHETICAL 26.8 KD PROTEIN IN INLA 5'REGION (ORFA) LENGTH = 248 COMBINED P-VALUE = 8.79e-27 E-VALUE = 2.9e-25 DIAGRAM: 4_[1]_126_[2]_68 [1] 2.4e-18 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++ + 1 MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQIIKANSGEAIFAKTDVTKREDNKKLVEL [2] 1.1e-15 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++++ +++ ++++ ++++ +++ 151 GAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVA DHB2_HUMAN no comment LENGTH = 387 COMBINED P-VALUE = 9.29e-27 E-VALUE = 3.1e-25 DIAGRAM: 81_[1]_127_[2]_129 [1] 5.4e-16 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++++ 76 ELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYS [2] 2.0e-18 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++++++++ ++++++++++++ 226 MERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (EC 1.1.1.56) (RDH) LENGTH = 249 COMBINED P-VALUE = 2.65e-26 E-VALUE = 8.7e-25 DIAGRAM: 13_[1]_123_[2]_63 [1] 4.3e-16 GKVVLITGCSSGIGKATAKHL ++++ ++++++++++++++++ 1 MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQV [2] 1.9e-17 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++ +++++++++++ 151 VVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESV DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYDROGENASE (EC 1.1.1.233) (NAM-DH) LENGTH = 270 COMBINED P-VALUE = 4.04e-26 E-VALUE = 1.3e-24 DIAGRAM: 13_[1]_128_[2]_79 [1] 4.7e-15 GKVVLITGCSSGIGKATAKHL ++++++++++++++++++++ 1 TTAGVSRRPGRLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAIDA [2] 2.2e-18 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ ++++++ +++++++++++++++ ++ 151 GSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILVNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRP FVT1_HUMAN no comment LENGTH = 332 COMBINED P-VALUE = 6.24e-26 E-VALUE = 2.1e-24 DIAGRAM: 31_[1]_131_[2]_120 [1] 5.2e-15 GKVVLITGCSSGIGKATAKHL + +++++++++++++++++++ 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE [2] 2.0e-18 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++++++ +++++++++++++++ 151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFA ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE (EC 1.3.1.28) LENGTH = 248 COMBINED P-VALUE = 2.02e-25 E-VALUE = 6.7e-24 DIAGRAM: 4_[1]_116_[2]_78 [1] 3.6e-17 GKVVLITGCSSGIGKATAKHL +++++++++++++++++++++ 1 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDA [2] 1.8e-15 SVYCASKFA +++++++++ 76 LVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAA VRMLTRSMAMEYAPHGIRVN ++++ + ++++ ++++++ 151 LKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFL 2BHD_STREX 20-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.53) LENGTH = 255 COMBINED P-VALUE = 4.68e-25 E-VALUE = 1.5e-23 DIAGRAM: 5_[1]_3_[1]_99_[2]_77 [1] [1] 4.4e-13 4.5e-05 GKVVLITGCSSGIGKATAKHL GKVVLITGCSSGIGKATAKHL ++++++++++++++ + +++ + +++ + ++++++ 1 MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAR [ 3 S + 76 EEFGSVDGLVNNAGISTGMFLETESVERFRKVVDINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTS 2] .2e-19 VYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++ +++++++ +++++ 151 SYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLL BDH_HUMAN D-BETA-HYDROXYBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.30) (BDH) (3-HYDROXYBUTYRATE DEHYDROGENASE) (FRAGMENT) LENGTH = 343 COMBINED P-VALUE = 7.26e-25 E-VALUE = 2.4e-23 DIAGRAM: 54_[1]_130_[2]_109 [1] 1.8e-15 GKVVLITGCSSGIGKATAKHL ++++++++++++ ++++++++ 1 GLRPPPPGRFSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHL [2] 6.5e-17 SVYCASKFAVRMLTRSMAME ++++ +++++++++ +++++ 151 GEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE YAPHGIRVN +++ +++++ 226 MYPLGVKVSVVEPGNFIAATSLYNPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID HMTR_LEIMA no comment LENGTH = 287 COMBINED P-VALUE = 1.33e-24 E-VALUE = 4.4e-23 DIAGRAM: 5_[1]_164_[2]_68 [1] 1.4e-12 GKVVLITGCSSGIGKATAKHL ++++++++++ +++++++ + 1 MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVS [2] 2.3e-19 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + +++++++++++++++++++++ +++++ 151 PYFLIKAFAHRSRHPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGL DHES_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) (20 ALPHA-HYDROXYSTEROID DEHYDROGENASE) (E2DH) (17-BETA-HSD) (PLACENTAL 17-BETA-HYDROXYSTEROID DEHYDROGENASE) LENGTH = 327 COMBINED P-VALUE = 5.97e-24 E-VALUE = 2e-22 DIAGRAM: 1_[1]_130_[2]_146 [1] 1.3e-14 GKVVLITGCSSGIGKATAKHL ++++++++++++++++ ++ 1 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAA [2] 8.7e-17 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++++ + + +++ + 151 FNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQV 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.51) LENGTH = 253 COMBINED P-VALUE = 1.62e-23 E-VALUE = 5.3e-22 DIAGRAM: 5_[1]_122_[2]_76 [1] 2.5e-15 GKVVLITGCSSGIGKATAKHL ++++++++++++++++ ++ + 1 TNRLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSEADWTLVMAAVQ [2 2. SV + 76 RRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQGIAAMKETGGSIINMASVSSWLPIEQYAG ] 1e-15 YCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++++++++++ +++++ ++ 151 YSASKAAVSALTRAAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQL BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (BILE ACID 7-DEHYDROXYLASE) (BILE ACID-INDUCIBLE PROTEIN) LENGTH = 249 COMBINED P-VALUE = 1.65e-23 E-VALUE = 5.5e-22 DIAGRAM: 5_[1]_128_[2]_66 [1] 1.0e-14 GKVVLITGCSSGIGKATAKHL +++ +++++ ++++++ ++ + 1 MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAA [2] 5.4e-16 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + +++++++++++ + +++ ++++++ 151 SLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVY GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DEHYDROGENASE (EC 1.1.1.140) (GLUCITOL-6- PHOSPHATE DEHYDROGENASE) (KETOSEPHOSPHATE REDUCTASE) LENGTH = 259 COMBINED P-VALUE = 8.98e-23 E-VALUE = 3e-21 DIAGRAM: 1_[1]_129_[2]_79 [1] 3.4e-10 GKVVLITGCSSGIGKATAKHL ++++++ ++++ ++ +++ + 1 MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSCLALSRGV [2] 8.7e-20 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + +++++++ +++++++++++++++++++ 151 NSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGC DHB3_HUMAN no comment LENGTH = 310 COMBINED P-VALUE = 1.18e-22 E-VALUE = 3.9e-21 DIAGRAM: 47_[1]_127_[2]_86 [1] 7.8e-15 GKVVLITGCSSGIGKATAKHL ++++++++++ +++++++ ++ 1 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYYKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV [2] 3.4e-15 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++++++++++++ +++ + + ++ 151 QSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDROGENASE (EC 1.3.1.-) LENGTH = 275 COMBINED P-VALUE = 1.63e-20 E-VALUE = 5.4e-19 DIAGRAM: 4_[1]_125_[2]_96 [1] 2.1e-14 GKVVLITGCSSGIGKATAKHL + ++++++++++++++++ ++ 1 MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVAR [2] 2.5e-13 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + ++++++++++++++++++++++ + 151 PLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEE LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC -.-.-.-) LENGTH = 305 COMBINED P-VALUE = 2.04e-20 E-VALUE = 6.7e-19 DIAGRAM: 5_[1]_128_[2]_122 [1] 1.4e-12 GKVVLITGCSSGIGKATAKHL ++++ +++++++ ++ +++ + 1 MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAAD [2] 3.7e-15 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++++++ +++++ +++ + ++++ ++ 151 SALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQ RFBB_NEIGO no comment LENGTH = 346 COMBINED P-VALUE = 2.09e-20 E-VALUE = 6.9e-19 DIAGRAM: 5_[1]_136_[2]_155 [1] 1.2e-12 GKVVLITGCSSGIGKATAKHL +++++++++++ ++ + +++ 1 MQTEGKKNILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDRAELDRVF [2] 3.4e-15 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++++++++ +++++++++ ++ ++ + 151 DLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDG DHCA_HUMAN no comment LENGTH = 276 COMBINED P-VALUE = 4.62e-19 E-VALUE = 1.5e-17 DIAGRAM: 3_[1]_166_[2]_57 [1] 3.4e-15 GKVVLITGCSSGIGKATAKHL ++++++++++++++++++++ 1 SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDF [2] 4.5e-11 SVYCASKFAVRMLTRSMAMEYAPHGIRVN ++++ ++ +++ +++ +++ +++++ 151 PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC ADH_DROME ALCOHOL DEHYDROGENASE (EC 1.1.1.1) LENGTH = 255 COMBINED P-VALUE = 4.42e-16 E-VALUE = 1.5e-14 DIAGRAM: 5_[1]_123_[2]_77 [1] 1.8e-10 GKVVLITGCSSGIGKATAKHL +++++ + +++++ +++++ 1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKL [ 1 S + 76 LKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVP 2] .1e-12 VYCASKFAVRMLTRSMAMEYAPHGIRVN +++ ++++++++++++++ ++++ + 151 VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKA FABI_ECOLI no comment LENGTH = 262 COMBINED P-VALUE = 1.59e-15 E-VALUE = 5.3e-14 DIAGRAM: 5_[1]_130_[2]_77 [1] 6.4e-10 GKVVLITGCSSGIGKATAKHL ++++++++ ++ + ++ ++ 1 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMF [2] 1.1e-12 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ +++++++ +++++ +++++++++ 151 RAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDV YURA_MYXXA no comment LENGTH = 258 COMBINED P-VALUE = 2.17e-14 E-VALUE = 7.1e-13 DIAGRAM: 157_[2]_72 [2] 8.3e-18 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + +++++++++ ++++++++++ ++++++ 151 GFRGLPATRYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRG PCR_PEA no comment LENGTH = 399 COMBINED P-VALUE = 2.49e-12 E-VALUE = 8.2e-11 DIAGRAM: 85_[1]_293 [1] 2.8e-15 GKVVLITGCSSGIGKATAKHL + +++++++++++++++++++ 76 SSSEGKKTLRKGNVVITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSAGLAKENYTIMHLDLASLDS MAS1_AGRRA no comment LENGTH = 476 COMBINED P-VALUE = 8.12e-11 E-VALUE = 2.7e-09 DIAGRAM: 244_[1]_124_[2]_58 [1] 6.2e-13 GKVVLITGCSSGIGKATAKHL ++++++ ++++++++++++++ 226 GRVLHFRRGFSHWTVEIHQSPVILVSGSNRGVGKAIAEDLIAHGYRLSLGARKVKDLEVAFGPQDEWLHYARFDA [2] 2.3e-05 SVYCASKFAVRMLTRSMAMEYAPHGIRVN + +++ ++ +++++ ++ + 376 NINSMSGQRVLNPLVGYNMTKHALGGLTKTTQHVGWDRRCAAIDICLGFVATDMSAWTDLIASKDMIQPEDIAKL CSGA_MYXXA no comment LENGTH = 166 COMBINED P-VALUE = 1.37e-09 E-VALUE = 4.5e-08 DIAGRAM: 85_[2]_52 [2] 5.8e-13 SVYCASKFAVRMLTRSMAMEYAPHGIRVN +++ ++++++ + ++++ ++++++ + 76 SLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNP ******************************************************************************** CPU: tlb-squirrel Time 0.030000 secs. mast tests/meme/meme.adh.zoops tests/adh.s