LOCUS NM_004236 1951 bp mRNA linear PRI 22-APR-2005 DEFINITION Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (COPS2), mRNA. ACCESSION NM_004236 VERSION NM_004236.1 GI:4759263 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1951) COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF084260.1. FEATURES Location/Qualifiers source 1..1951 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q21.2" gene 1..1951 /gene="COPS2" /note="synonyms: CSN2, SGN2, ALIEN, TRIP15" /db_xref="GeneID:9318" /db_xref="HPRD:HPRD_05146" /db_xref="MIM:604508" CDS 16..1347 /gene="COPS2" /function="role in signal transduction" /note="thyroid receptor interacting protein 15; go_component: cytoplasm [goid 0005737] [evidence IDA] [pmid 9535219]; go_component: signalosome complex [goid 0008180] [evidence IDA] [pmid 9535219]; go_function: protein binding [goid 0005515] [evidence TAS] [pmid 9535219]; go_function: signal transducer activity [goid 0004871] [evidence NAS] [pmid 9535219]; go_process: signal transduction [goid 0007165] [evidence NAS] [pmid 9535219]; go_process: transcription from RNA polymerase II promoter [goid 0006366] [evidence TAS] [pmid 7776974]" /codon_start=1 /product="COP9 constitutive photomorphogenic homolog subunit 2" /protein_id="NP_004227.1" /db_xref="GI:4759264" /db_xref="GeneID:9318" /db_xref="HPRD:HPRD_05146" /db_xref="MIM:604508" /translation="MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKE ILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA" misc_feature 1048..1296 /gene="COPS2" /note="PINT; Region: motif in proteasome subunits, Int-6, Nip-1 and TRIP-15" /db_xref="CDD:24204" variation complement(492) /gene="COPS2" /replace="a" /replace="g" /db_xref="dbSNP:17473148" variation 1114 /gene="COPS2" /replace="a" /replace="t" /db_xref="dbSNP:1802452" variation complement(1464) /gene="COPS2" /replace="c" /replace="t" /db_xref="dbSNP:16962079" ORIGIN 1 tcggcacgag ccaagatgtc tgacatggag gatgatttca tgtgcgatga tgaggaggac // LOCUS NM_010664 1386 bp mRNA linear ROD 15-APR-2005 DEFINITION Mus musculus keratin complex 1, acidic, gene 18 (Krt1-18), mRNA. ACCESSION NM_010664 VERSION NM_010664.1 GI:6754481 KEYWORDS . SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 1386) AUTHORS Gilbert,S., Loranger,A. and Marceau,N. TITLE Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells JOURNAL Mol. Cell. Biol. 24 (16), 7072-7081 (2004) PUBMED 15282307 REMARK GeneRIF: Data show that inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not keratin 8 (K8)-null mouse hepatocytes to apoptosis, and is associated with a reduction in c-Flip protein, part of a K8/K18 complex. REFERENCE 2 (bases 1 to 1386) AUTHORS Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M., Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S., Kamal,M., Patterson,N., Lander,E.S. and Mann,M. TITLE Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M11686.1. FEATURES Location/Qualifiers source 1..1386 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="15" /map="15 58.86 cM" gene 1..1386 /gene="Krt1-18" /note="synonyms: K18, Endo B" /db_xref="GeneID:16668" /db_xref="MGI:96692" CDS 55..1326 /gene="Krt1-18" /note="keratin 18; go_component: mitochondrion [goid 0005739] [evidence IDA] [pmid 14651853]; go_component: intermediate filament [goid 0005882] [evidence IEA]; go_function: structural molecule activity [goid 0005198] [evidence IEA]; go_function: structural constituent of cytoskeleton [goid 0005200] [evidence IEA]; go_process: cytoskeleton organization and biogenesis [goid 0007010] [evidence IEA]" /codon_start=1 /product="keratin complex 1, acidic, gene 18" /protein_id="NP_034794.1" /db_xref="GI:6754482" /db_xref="GeneID:16668" /db_xref="MGI:96692" /translation="MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSG NSMQTVQKTTTRKIVDGRVVSETNDTRVLRH" misc_feature 268..1197 /gene="Krt1-18" /note="Filament; Region: Intermediate filament protein" /db_xref="CDD:16593" variation 289 /gene="Krt1-18" /replace="c" /replace="t" /db_xref="dbSNP:13469068" variation 1079 /gene="Krt1-18" /replace="c" /replace="t" /db_xref="dbSNP:13469067" ORIGIN 1 tccgcggcgg aactcctgtt ctggtctctc gcttcgctct cctctccaga caagatgagc // LOCUS NM_009304 1527 bp mRNA linear ROD 15-APR-2005 DEFINITION Mus musculus synaptogyrin 2 (Syngr2), mRNA. ACCESSION NM_009304 VERSION NM_009304.1 GI:7106428 KEYWORDS . SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 1527) AUTHORS Belfort,G.M. and Kandror,K.V. TITLE Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells JOURNAL J. Biol. Chem. 278 (48), 47971-47978 (2003) PUBMED 12928441 REMARK GeneRIF: Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF151985.1. FEATURES Location/Qualifiers source 1..1527 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="11" gene 1..1527 /gene="Syngr2" /note="synonyms: Clast2, cellugyrin" /db_xref="GeneID:20973" /db_xref="MGI:1328324" CDS 36..710 /gene="Syngr2" /note="go_component: membrane [goid 0016020] [evidence IEA]; go_component: integral to membrane [goid 0016021] [evidence IEA]; go_component: synaptic vesicle [goid 0008021] [evidence IDA] [pmid 12928441]; go_process: protein targeting [goid 0006605] [evidence ISS] [pmid 12928441]" /codon_start=1 /product="synaptogyrin 2" /protein_id="NP_033330.1" /db_xref="GI:7106429" /db_xref="GeneID:20973" /db_xref="MGI:1328324" /translation="MESGAYGAANAGGSFDLRRFLSQPQVVTRLVSMVLALIVFSCIF GEGYTNIHTSDQLYCVFNQNEDACRYGSAIGVLAFLASAFFLVVDAFFSQISNATDRK YLVIGDLLFSALWTFLWFVGFCFLTNQWAATKPQDVRVGADSARAAITFSFFSIFSWG VLASLAYQRYKAGVDAFIQNYVDPTPDPNTAYASYPSASVENYQQPPFTQNVETTEGY QPPPVY" misc_feature 93..548 /gene="Syngr2" /note="MARVEL; Region: Membrane-associating domain" /db_xref="CDD:25727" variation 338 /gene="Syngr2" /replace="a" /replace="c" /db_xref="dbSNP:13469056" variation 611 /gene="Syngr2" /replace="c" /replace="t" /db_xref="dbSNP:13469057" variation 623 /gene="Syngr2" /replace="c" /replace="t" /db_xref="dbSNP:13469060" variation 679 /gene="Syngr2" /replace="c" /replace="t" /db_xref="dbSNP:13469061" variation 1217 /gene="Syngr2" /replace="g" /replace="t" /db_xref="dbSNP:13469062" ORIGIN 1 ctacgtcagg gccgcggctc ggtggcgaaa cggacatgga gagcggggcc tatggcgcgg 1501 ataaacggtt tttctcccct gacgtag //