This track displays the p-values (-log10) of the Bipolar disease pooled data reported by NIMH in their Molecular Psychiatry paper. They performed a Genome Wide Association study on two populations:
Reported p-values are taken for each of the Illumina550 probes on the genome, then logged and minused for visualization purposes. These p-values have not been Bonferroni adjusted. US cases had an affected sibling. 96% of German sample reported both parents and grandparents were born in Germany. The German sample was used to replicate the US sample. The following conditions were applied to the US sample: pval < 0.05, Odds Ratio > 1.4 or < 0.71, Relative Allele Frequency > 0.05, required to be near a known gene, and finally replicated in the German sample with pval < 0.05. The results left 88 SNPs in 80 genes.
When individually genotyped, 76% remained significant in US, and 36% of those remained significant in the German sample. Combined p-values were also calculated for the SNPs yielding the most significant find rs1012053 pvalue = 1.5e-8 for the gene DGKH diacylglyceral kinase, which is still significant after Bonferroni adjustment. DGKH protein is key in the lithium-sensitive phosphatidyl inositol pathway. Several other risk SNPs were identified of small effect.
For the complete dataset, visit The National Instututes of Mental Health (NIMH) MAP Genetics Web Site.
NIMH Bipolar Disorder Consortium. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder, by AE Baum, N Akula, M Cabanero, I Cardona, W Corona, B Klemens, TG Schulze, S Cichon, M Rietschel, MM Nathen, A Georgi, J Schumacher, M Schwarz, R Abou Jamra, S Hofels, P Propping, J Satagopan, NIMH Genetics Initiative Bipolar Disorder Consortium, SD Detera-Wadleigh, J Hardy, and FJ McMahon.
Molecular Psychiatry 2007, (1-11)
In addition, those using data from the NIMH sample should cite the NIMH Bipolar Disorder Consortium by use of the language specified in the Distribution Agreement from the NIMH Center for Genetic Studies (http:/nimhgenetics.org).