This super-track combines related tracks of ChIP-chip data generated by the ENCODE group at the Sanger Institute. ChIP-chip, also known as genome-wide location analysis, is a technique for isolation and identification of DNA sequences bound by specific proteins in cells, including histones. Histone methylation and acetylation serves as a stable genomic imprint that regulates gene expression and other epigenetic phenomena. These histones are found in transcriptionally active domains called euchromatin.
These tracks contain ChIP-chip data for H3 and H4 histones in multiple cell lines, including HeLa (cervical carcinoma), GM06990 (lymphoblastoid), K562 (myeloid leukemia), and HFL-1 (embryonic lung fibroblast). Experiments were conducted with antibodies to histones with different post-translational modification marks. Data are displayed as signals as well as hits and peak centers identified by hidden Markov model (HMM) analysis.
The data were generated by the ENCODE investigators at the Wellcome Trust Sanger Institute, Hinxton, UK. Contacts: Ian Dunham and Christoph Koch.
The HMM analysis was performed at the EBI by Paul Flicek.
Raw data may be downloaded from the Sanger Institute website at ftp://ftp.sanger.ac.uk/pub/encode.