Description
DNA methylation is essential for normal development and is
associated with silencing large regions of DNA through processes such
as imprinting and X-chromosome inactivation. The majority of CpG
dinucleotides are methylated in mammals. Unmethylated CpGs occur
in segments called "CpG islands", which often lie in the upstream of
genes in the regulatory regions and impact transcription.
Display Conventions
These tracks depict the degree of methylation in CpG islands. CpG
islands with stronger methylation scores are rendered in brighter
colors, as described in each track details page.
Credits
These data were generated and analyzed as part of the ENCODE project, a
genome-wide consortium project with the aim of cataloging all
functional elements in the human genome. This effort includes
collecting a variety of data over a specific set of cell types.
Consequently,
data
related
to
these tracks be available under ENCODE
tracks.
References
Illingworth RS, Bird AP. CpG islands--'a rough guide'.
FEBS Lett. 2009 Jun 5;583(11):1713-20.
Caiafa P, Zampieri M. DNA methylation and
chromatin structure: the puzzling CpG islands. J Cell Biochem. 2005
Feb 1;94(2):257-65.
Latham T, Gilbert N, Ramsahoye B. DNA methylation in mouse embryonic stem
cells and development. Cell Tissue Res. 2008
Jan;331(1):31-55,
Data Release Policy
Data users may freely use ENCODE data, but may not, without prior
consent, submit publications that use an unpublished ENCODE dataset
until nine months following the release of the dataset. This date is
listed in the Restricted Until column on the track configuration page
and the download page. The full data release policy for ENCODE is
available here.