This track displays maps of chromatin state of ENCODE cell types. Chemical
modifications (methylation, acylation) to the histone proteins present
in chromatin influence gene expression by changing how accessible the
chromatin is to transcription.
The ChIP-seq method involves cross-linking histones and other DNA
associated proteins to genomic DNA within cells using formaldehyde. The
cross-linked chromatin is subsequently extracted, mechanically sheared,
and immunoprecipitated using specific antibodies. After reversal of
cross-links, the immunoprecipitated DNA is sequenced and mapped to the
human reference genome. The relative enrichment of each antibody-target
(epitope) across the genome is inferred from the density of mapped
fragments.