Description
This column shows the predicted transcription factor binding
sites that correlate with expression of the gene.
Methods
The approach underlying this annotation is described in Segal, E. et al.,
Genome-wide discovery of transcriptional modules from DNA
sequence and gene expression, Bioinformatics 19(Suppl 1),
i273-i282 (2003).
The analysis was performed on various pre-existing microarray datasets.
A regulatory module is comprised of a set of genes predicted to be regulated
by the same combination of DNA sequence motifs. Predictions are based on the
co-expression of the set of genes in the module and on the appearance of
common combinations of motifs in the upstream regions of genes assigned to
the same module.
Credits
Thanks to Eran
Segal for providing the data analysis that forms the basis for this
column.