Here's the SCOP analysis: RefSeq coding genes: 18464 (90.36%) non-RefSeq coding genes: 1969 (9.64%) RefSeq with scop: 12815 (69.41%) non-RefSeq with scop: 807 (40.99%) RefSeq total unique domains in proteins: 24411 Top 10 RefSeq domains 3.33% (813) 52540 "P-loop containing nucleoside triphosphate hydrolases" 2.99% (731) 81321 "Family A G protein-coupled receptor-like" 2.61% (636) 57667 "C2H2 and C2HC zinc fingers" 2.03% (496) 56112 "Protein kinase-like (PK-like)" 1.99% (485) 48726 "Immunoglobulin" 1.59% (389) 48695 "Multiheme cytochromes" 1.51% (368) 50729 "PH domain-like" 1.43% (348) 50969 "YVTN repeat-like/Quinoprotein amine dehydrogenase" 1.31% (320) 57850 "RING/U-box" 1.28% (312) 101898 "NHL repeat" non-RefSeq total unique domains in proteins: 1401 Top 10 non-refSeq domains. 8.92% (125) 48726 "Immunoglobulin" 4.93% (69) 57667 "C2H2 and C2HC zinc fingers" 3.35% (47) 48695 "Multiheme cytochromes" 3.07% (43) 52540 "P-loop containing nucleoside triphosphate hydrolases" 2.93% (41) 109640 "KRAB domain (Kruppel-associated box, Pfam 01352)" 2.14% (30) 50729 "PH domain-like" 2.00% (28) 48371 "ARM repeat" 1.78% (25) 56112 "Protein kinase-like (PK-like)" 1.71% (24) 48403 "Ankyrin repeat" 1.43% (20) 81321 "Family A G protein-coupled receptor-like" I wonder what SCOP is calling the 7 transmembrane receptor (rhodopsin family). Maybe Family A G protein-coupled-receptor-like?