AP-2alpha Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5' -GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle (by similarity). GeneCard:TFAP2A http://www.genecards.org/cgi-bin/carddisp.pl?gene=TFAP2A AP-2gamma Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. GeneCard:GTFAP2C http://www.genecards.org/cgi-bin/carddisp.pl?gene=TFAP2C ARID3A This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. (provided by RefSeq) GeneCard:ARID3A http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARID3A ATF1 ATF1 is a bZip transcription factor from the CREB family. ATF1 binds to both cAMP response elements (TGACGTCA). GeneCard:ATF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATF1 ATF2 ATF2 is a stress inducible basic leucine zipper transcription factor from the CREB family. ATF2 is phosphorylated at threonine residues 69 and 71 by JNK or p38 mitogen activated protein kinases. Mutation of these residues leads to the loss of ATF2 transactivation in vitro. GeneCard:ATF2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATF2 ATF3 Activating transcription factor 3. A bZIP transcription factor and member of the Ca2+/cAMP response element-binding (CREB) protein family. ATF3 is found to act both as an activator and repressor of transcription. GeneCard:ATF3 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATF3 Bach1 This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. (provided by RefSeq) GeneCard:BACH1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BACH1 BAF155 BAF155 (SMARCC1, Brg1-Associated Factor, 155 kD) is a ubiquitous component of the SWI/SNF chromatin-remodeling complex. GeneCard:SMARCC1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCC1 BAF170 BAF170 (Brg1-Associated Factor, 170 kD) is a ubiquitous component of the SWI/SNF chromatin-remodeling complex. GeneCard:SMARCC2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCC2 BATF The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. GeneCard:BATF http://www.genecards.org/cgi-bin/carddisp.pl?gene=BATF BCL11A This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis,is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity) GeneCard:BCL11A http://www.genecards.org/cgi-bin/carddisp.pl?gene=BCL11A BCL3 This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. (Provided by RefSeq). GeneCard:BCL3 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BCL3 BCLAF1 This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins (RefSeq). GeneCard:BCLAF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BCLAF1 BDP1 'B double-prime 1', subunit of RNA polymerase III transcription initiation factor IIIB GeneCard:BDP1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BDP1 BHLHE40 This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differe GeneCard:BHLHE40 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BHLHE40 BRCA1 Nuclear phosphoprotein that plays a role in maintaining genomic stability, and acts as a tumor suppressor. Associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. GeneCard:BRCA1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BRCA1 BRF1 'B-related factor 1', subunit of RNA polymerase III transcription initiation factor IIIB GeneCard:BRF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BRF1 BRF2 Brf2 is a component of an alternate form of the RNA Polymerase III transcription factor TFIIIB. GeneCard:BRF2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BRF2 BRG1 Brg1 (SMARCA4) is an ATPase subunit of the SWI/SNF chromatin-remodeling complex. GeneCard:SMARCA4 http://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCA4 BTF3 This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. (provided by RefSeq) GeneCard:BTF3 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BTF3 c-Fos Heterodimer of Fos and Jun constitute transcription factor AP1. Proto-oncogene c-Jun is a leucine-zipper. GeneCard:FOS http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOS c-Jun Heterodimer of Fos and Jun constitute transcription factor AP1. Proto-oncogene c-Jun is a leucine-zipper. GeneCard:JUN http://www.genecards.org/cgi-bin/carddisp.pl?gene=JUN c-Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. GeneCard:MYB http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYB c-Myc transcription factor; c-Myc-encoded proteins function in cell proliferation,differentiation and neoplastic disease GeneCard:MYC http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYC CCNT2 CycT2 is one of three cyclins that can form a heterodimer with cyclin-dependent kinase 9 (CDK9). The heterodimer is known as positive elongation factor b (P-TEFb) and is responsible for the phosphophorylation of Ser2 of the heptad repeat in the C-terminal domain of RNA polymerase II as well as the negative elongation factors DSIF (hSpt4/hSpt5) and NELF. Phosphorylation of RNA polymerase II and the negative elongation factors by P-TEFb promotes elongation. CycT2 contains a leucine rich domain capable of binding to the C-terminal domain of RNA polymerase II. GeneCard:CCNT2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNT2 CDK9 Cyclin dependent kinase 9 (CDK9) heterodimerizes with Cyclin T1 or Cyclin T2. The heterodimer is also known as positive elongation factor B (P-TEFb) and is responsible for the phosphorylation of Ser2 of the RNA polymerase II C-terminal GeneCard:CDK9 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDK9&search=cdk9 CEBPB epitope mapping at the C-terminus of C/EBP-beta of rat origin GeneCard:CEBPB http://www.genecards.org/cgi-bin/carddisp.pl?gene=CEBPB CEBPD The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11 (provided by RefSeq). GeneCard:CEBPD http://www.genecards.org/cgi-bin/carddisp.pl?gene=CEBPD CEBPZ Stimulates transcription from the HSP70 promoter. GeneCard:CEBPZ http://www.genecards.org/cgi-bin/carddisp.pl?gene=CEBPZ CHD1 CHD1 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD1 has been shown to interact with the transcriptional corepressor NCoR and histone deacetylase 1 indicating a role in transcriptional regulation. CHD1 has also been shown to interact with the Paf1 complex and Rtf1 implicating an additional role in transcriptional elongation. Alternate names for CHD1 include chromodomain-helicase-DNA-binding protein 1, ATP-dependent helicase CHD1, and DKFZp686E2337. GeneCard:CHD1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CHD1 CHD2 CHD family of proteins are characterized by presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. GeneCard:CHD2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CHD2 CREB1 CREB is a basic leucine zipper transcription factor. CREB is activated by phosphorylation of Ser133 in response to a range of stimuli by including a number of transcription factors PKA, CAMK and MAPKs. CREB is ubiquitously expressed, but has been specifically implicated in the development in neurite outgrowth and neuronal differentiation. GeneCard:CREB1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CREB1 CTCF CTCF zinc finger transcription factor. A sequence specific DNA binding protein that functions as an insulator, blocking enhancer activity. It has also been suggested to block the spreading of chromatin structure in certain instances. GeneCard:CTCF http://www.genecards.org/cgi-bin/carddisp.pl?gene=CTCF CTCFL CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. (provided by RefSeq) GeneCard:CTCFL http://www.genecards.org/cgi-bin/carddisp.pl?gene=CTCFL CtBP1 C-terminal binding protein 1 GeneCard:CTBP1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CTBP1 CtBP2 C-terminal binding protein 2 GeneCard:CTBP2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CTBP2 CycT1 Cyclin T1 is a cyclin that forms heterodimers with the cyclin dependent kinase CDK9. CDK9 is responsible for phosphorylating Ser2 of the heptad repeat of the C-terminal domain of the large subunit of RNA polymerase II, and negative elongation factors NELF and DSIF. Cyclin T1 makes contacts with RNAPII and nascent mRNA and as such recruits CDK9 to facilitate release of stalled RNAPII and productive elongation. GeneCard:CCNT1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNT1 E2F1 E2F1, the original member of the E2F family of transcription factors, was identified as a cellular protein with DNA binding activity associated with the adenovirus E2 gene promoter. E2F1 is cell cycle regulated with very low levels in early G1, then increasing levels as cells move from G1 to S, and highest levels of protein at the G1/S boundary, which is consistent with its role in S-phase entry. GeneCard:E2F1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=E2F1 E2F4 mapping at the C-terminus of E2F4 of human origin GeneCard:E2F4 http://www.genecards.org/cgi-bin/carddisp.pl?gene=E2F4 E2F6 This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms (RefSeq). GeneCard:E2F6 http://www.genecards.org/cgi-bin/carddisp.pl?gene=E2F6 EBF1 Early B-cell factor 1. Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). EBF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=EBF1 eGFP-BACH1 This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members (provided by RefSeq) GeneCard:BACH1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BACH1 eGFP-CCNE1 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (provided by RefSeq) GeneCard:CCNE1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNE1 eGFP-CDKN1B This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1 (provided by RefSeq) GeneCard:CDKN1B http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDKN1B eGFP-E2F1 The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses (provided by RefSeq) GeneCard:E2F1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=E2F1 eGFP-EKLF1 This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. (provided by RefSeq) GeneCard:EKLF1 missing eGFP-ELF1 This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants (provided by RefSeq) GeneCard:ELF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ELF1 eGFP-ESR This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. (provided by RefSeq) GeneCard:ESR http://www.genecards.org/cgi-bin/carddisp.pl?gene=ESR1 FOS Fos GeneCard:FOS http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOS GATA2 GATA2 GeneCard:GATA2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA2 HDAC8 HDAC8 GeneCard:HDAC8 http://www.genecards.org/cgi-bin/carddisp.pl?gene=HDAC8 eGFP-HMGB1 DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. (provided by RefSeq) GeneCard:HMGB1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMGB1 eGFP-ILF2 Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. (provided by RefSeq) GeneCard:ILF2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ILF2 JunB JunB GeneCard:JUNB http://www.genecards.org/cgi-bin/carddisp.pl?gene=JUNB JunD JunD GeneCard:JUND http://www.genecards.org/cgi-bin/carddisp.pl?gene=JUND eGFP-MLL5 This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. (provided by RefSeq) GeneCard:MLL5 http://www.genecards.org/cgi-bin/carddisp.pl?gene=MLL5 eGFP-NCOR1 This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17 (provided by RefSeq) GeneCard:NCOR1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=NCOR1 eGFP-NF90 NF90 (nuclear factor of activated T cells 90 kDa), also known as NFAR is a ubiquitously expressed nuclear protein that exists in a heterodimer with NF45. (provided by RefSeq) GeneCard:ILF3 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ILF3 NR4A1 NR4A1 GeneCard:NR4A1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=Nr4a1 eGFP-SMARCA1 This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. (provided by RefSeq) GeneCard:SMARCA1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCA1 eGFP-SMARCA2 The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes (provided by RefSeq) GeneCard:SMARCA2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCA2 eGFP-STAT1 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6 (provided by RefSeq) GeneCard:STAT1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=STAT1 ELF1 This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq) GeneCard:ELF1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ELF1 ELK4 This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (provided by RefSeq) GeneCard:ELK4 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ELK4 ERalpha_a This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5-prime UTRs and use different promoters. (provided by RefSeq) GeneCard:ESR1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ESR1&search=ESR1 ERalpha_b This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5-prime UTRs and use different promoters. (provided by RefSeq) GeneCard:ESR1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ESR1 EGR1 Egr-1, Egr-2, Egr-3 and Egr-4 are nuclear transcription factors belonging to the Egr C2H2-type zinc-finger protein family and containing three C2H2-type zinc fingers. As immediate early proteins, Egr transcription factors are rapidly induced by diverse extracellular stimuli. Egr proteins are subject to tight differential control through diverse mechanisms at several levels of regulation including transcriptional, translational and post-translational (including glyco- sylation, phosphorylation and redox) mechanisms and protein-protein inter- action. Egr-1 binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site), there- by activating transcription of target genes whose products are required for mitogenisis and differentiation. Egr-2 binds specific DNA sites located in the promoter region of HoxA4. Egr-2 defects cause congenital hypomyelination neuropathy (also designated Charcot-Marie-tooth disease) and Dejerine- Sottas neuropathology (also designated hereditary motor and sensory neuro- pathy III. Egr-3 is involved in muscle spindle development and is expressed in T cells 20 minutes following activation. EGR-4 binds to the EGR consensus motif GCGTGGGCG, functions as a transcriptional repressor, and displays autoregulatory activities, downregulating its on gene promoter in a dose dependent manner. GeneCard:EGR1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=EGR1 ERRA epitope corresponding to amino acids 81-160 mapping near the N-terminus of ERRalpha of human origin GeneCard:ESRRA http://www.genecards.org/cgi-bin/carddisp.pl?gene=ESRRA ETS1 ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis GeneCard:ETS1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=ETS1 EZH2 EZH2 (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers. GeneCard:EZH2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=EZH2 FOSL1 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (provided by RefSeq) GeneCard:FOSL1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOSL1 FOSL2 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. GeneCard:FOSL2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOSL2 FOXA1 This gene encodes a member of the forehead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver (RefSeq). GeneCard:FOXA1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXA1 FOXA2 The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. (provided by RefSeq) GeneCard:FOXA2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXA2 FOXM1 The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2011) GeneCard:FOXM1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXM1 FOXP2 This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. Transcriptional repressor, involved in the development of speech GeneCard:FOXP2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXP2 GABP The transcription factor GA-binding protein (GABP) is composed of two subunits, alpha and beta. Alpha binds to a specific DNA sequence. GeneCard:GABPB1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=GABPB1 GATA1 GATA-1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG} within regulatory regions of globin genes and of other genes expressed in erythroid cells. GeneCard:GATA1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA1 GATA3 This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is a n important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (provided by RefSeq). GeneCard:GATA3 http://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA3 GCN5 KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. Acetylation of histones gives a specific tag for epigenetic transcription activation. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the SAGA and ATAC complexes, complexes with histone acetyltransferase activities on histones H3 and H4 GeneCard:KAT2A http://www.genecards.org/cgi-bin/carddisp.pl?gene=KAT2A&search=gcn5 GR Glucocorticoid Receptor GeneCard:NR3C1 http://www.genecards.org/cgi-bin/carddisp.pl?gene=NR3C1