Mouse Resources at Wellcome Trust Centre for Human Genetics

• Jonathan Flint's Home Page
• Richard Mott's Home Page
• William Valdar's Home Page

• Mouse Haplotype Structure
• Wellcome-CTC Mouse Strain SNP Genotype Set
• QTL mapping using HAPPY
• Heterogeneous Stock Multiple Phenotyping Project
• QTL Mapping with Outbred MF1 Mice
• QTL Mapping Strategies
• Quantitative Trait Nucleotide Analysis
• Estimation of the probability of ENU-induced coding mutations

• Relevant Publications
  • Mott et al (2000) A method for fine-mapping quantitative trait loci in outbred animal stocks Proc Natl Acad Sci USA, 97(23):12649-12654.
  • Mott R and Flint J (2002) Simultaneous Detection and Fine-mapping of Quantitative Trait Loci in Mice using Heterogenous Stocks Genetics 160:1609-1618
  • Valdar W, Flint J and Mott R (2003) QTL fine-mapping using Recombinant-Inbred Heterogeneous Stocks and In-Vitro Heterogeneous Stocks. Mammalian Genome 14:830-838.
  • Binnaz Yalcin, Jan Fullerton, Sue Miller, David Keays, Saffron Brady, Amarjit Bhomra, Andrew Jefferson, Emanuela Volpi, Richard Copley, Jonathan Flint, Richard Mott. (2004)Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice Proc Natl Acad Sci USA, 101:9734-9739.
  • Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet. 2004 Nov;36(11):1197-202. pubmed
  • Yalcin B, Flint J, Mott R. (2005) Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics. 2005 Oct;171(2):673-81. pubmed .
  • Valdar W, Flint J, Mott R.(2006) Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics. 172(3):1783-97. pubmed
  • Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet. 2006 Aug;38(8):879-87. pubmed.
  • Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins NJ, Mott R, Flint J.(2006) Genetic and environmental effects on complex traits in mice. Genetics. 2006 Aug 3; [Epub ahead of print] pubmed

Contact Richard Mott for more details.